Psilocybin
Also known as: Magic Mushrooms, Shrooms
Category: Classic psychedelic (tryptamine)
Psilocybin is a naturally occurring compound found in over 180 species of mushrooms, many of which have been used in traditional healing and spiritual practices for generations. Typically taken by eating dried or fresh mushrooms, brewing them into tea, or consuming capsules, psilocybin is most often ingested orally. Effects usually begin within 30 to 60 minutes, peaking between 1 to 3 hours, and the overall journey can last around 6 to 8 hours—though the sense of time often stretches or dissolves entirely.
History & Culture
For thousands of years, Indigenous communities in Mexico and Central America have used psilocybin mushrooms in ceremony, healing, and spiritual practice.
In the 1950s and ’60s, Western researchers began exploring psilocybin’s potential in psychiatry and psychotherapy, though LSD received more focus.
In 1971, psilocybin research was effectively shut down in the U.S. when the Controlled Substances Act classified it as a Schedule I drug, alongside LSD and heroin.
In 2000, scientists at Johns Hopkins University gained approval to resume human research with psilocybin—marking the start of a modern scientific renaissance.
A pivotal 2006 study showed that psilocybin could induce deeply meaningful, mystical experiences, with long-term psychological and spiritual impact.
Effects
Visual enhancements, emotional fluidity, introspection, ego softening, often accompanied by laughter, awe, or tears.
Risks & Side Effects
Short-term anxiety or confusion.
Digestive upset possible.
Most common, psilocybin can cause nausea, vomiting, and headache, and can increase heart rate and blood pressure.
Avoid in pregnancy or with predisposed psychiatric conditions.
Microdosing
Involves taking very small, sub-perceptual doses of psilocybin (typically 1/10 to 1/20 of a full dose)
Reported benefits include increased focus, creativity, emotional balance, and productivity
Some users report relief from migraines, cluster headaches, or low-grade anxiety
Popular among creatives, technologists, and wellness seekers
Scientific evidence is still emerging — most benefits remain anecdotal
Long-term effects and risks are not fully known
Not recommended without caution if you're on SSRIs or managing mental health conditions
If exploring, use a structured protocol and consult a professional when possible
Duration & Onset
Onset: 30–60 minutes
Peak: 2–3 hours
Total: 4–6 hours (occasionally longer)
Dosage
Microdose: 0.1–0.5 g dried
Common: 1.5–3.5 g
High: 4–5+ g
Interactions
Psilocybin’s effects can be diminished by SSRIs and other antidepressants, while MAOIs may potentiate or unpredictably intensify the experience. Combining psilocybin with stimulants, alcohol, or dissociatives can increase the risk of confusion, anxiety, or physiological stress.
If you’re taking prescription medications or have a diagnosed mental health condition, always consult a medical professional or qualified psychedelic-informed therapist before use. Drug interactions can be complex, and set, setting, and personal health history all matter.
Therapeutic & Cultural Resonance
Extensively researched for depression, PTSD, addiction, and existential distress. Emphasizes symbolic narratives and landscape communion.
“Psilocybin can help us break down the barriers between ourselves and others and foster a sense of empathy and compassion."
- Katherine MacLean
Integration Tips
Journal experiences, reflect with peers, guides and therapists, walk in nature, and allow space for emerging insights over following days and weeks.
