2C-B
Also known as: Nexus, Bees, Bromo
Category: Synthetic psychedelic (phenethylamine)
2C-B (4-bromo-2,5-dimethoxyphenethylamine) is a semi-synthetic psychedelic compound first synthesized by chemist Alexander Shulgin in 1974. Known for its hybrid nature, it bridges the gap between empathogens (like MDMA) and classic psychedelics (like LSD or mescaline), offering a unique mix of emotional openness, sensory enhancement, and visual distortion—often without overwhelming ego loss or intense introspection. Users commonly describe it as both playful and insightful, with a distinctly sensual or social edge.
History & Culture
Synthesized in 1974 by Shulgin, who originally explored its use as a potential psychotherapeutic aid, especially in couples therapy.
In the 1980s and early ’90s, it gained popularity in Europe and South America as a legal alternative to MDMA, sold under names like “Nexus.”
It was briefly marketed by some as a sexual enhancer and even prescribed in limited therapeutic contexts before becoming controlled.
Criminalized in the U.S. in 1995 and later scheduled internationally, though it remains part of underground psychedelic culture.
In the 2010s, 2C-B began appearing in street blends like “pink cocaine” (also called “tusi” or “tucibi”), especially in South America and Europe—though these mixtures often contain little or no actual 2C-B and are instead cut with stimulants, anesthetics, and other synthetic drugs, increasing the risks of misidentification and overdose.
Still popular in club scenes, at festivals, and in intentional ceremonial or therapeutic micro-group work.
Effects
2C-B’s effects can be highly dose-dependent: At low-to-moderate doses, it tends to be warm, clear, and emotionally connected. At higher doses, more classic psychedelic features emerge—intensified visuals, tracers, pattern recognition, and altered time perception.
Risks & Side Effects
Nausea, muscle tension, or body temperature fluctuations (especially at high doses)
Anxiety, confusion, or emotional overwhelm—especially in stimulating environments
Rarely, users report emotional lability or “comedown” symptoms like irritability
May increase heart rate and blood pressure—use caution with preexisting conditions
Long-term psychological side effects are rare, but underreported
Some experience a "synthetic" or emotionally raw feeling during the offset
Duration & Onset
Onset: 30–90 minutes (oral)
Peak: 1–3 hours
Total duration: 4–6 hours
Afterglow: Mild, can last several hours post-peak
Dosage
Low: 5–10 mg – threshold perceptual shifts, body awareness
Common: 15–25 mg – full psychedelic and empathogenic effects
High: 30+ mg – intense visuals, possible anxiety or body discomfort
Note: effects can vary widely depending on set, setting, and sensitivity
Interactions
Avoid combining with SSRIs, MAOIs, or other stimulants. Mixing with alcohol can be unpredictable, sometimes dulling clarity or amplifying nausea. Combining with other psychedelics may lead to confused states or overwhelming intensity.
As always, test substances for purity (2C-B is often misrepresented or adulterated) and if you’re taking prescription medications or have a diagnosed mental health condition, always consult a medical professional or qualified psychedelic-informed therapist before use. Drug interactions can be complex, and set, setting, and personal health history all matter.
Therapeutic & Cultural Resonance
Though not as widely studied clinically as psilocybin or MDMA, 2C-B is increasingly used in underground therapeutic settings, especially in Europe and South America. Some facilitators use it for:
Couples therapy – due to its blend of openness and introspective clarity
Creative exploration – for its playful visuals and emotional malleability
Self-inquiry – offering a “less heavy” route into altered states
In ceremonial contexts, it’s seen as a gentler psychedelic gateway for those curious but hesitant to engage with more intense substances.
“If LSD is a teacher, and MDMA is a healer, 2C-B is a flirt.”- popular saying in psychedelic circles
Integration Tips
Because of its emotional clarity and relatively short duration, many users find 2C-B easier to integrate than classic tryptamines. Still, meaningful reflections can arise and are worth tending to. Use movement or somatic integration to connect insight with body memory. Spend time in nature, art, or intentional dialogue—2C-B often stimulates a sense of creativity and social flow.
Avoid immediate redosing—appreciate its nuance as a stand-alone
